Systems and Synthetic Biology
We aim to understand microbial gene regulatory networks and engineer microbes for addressing energy, environmental, and health issues. Specifically, we are interested in developing synthetic biology tools, constructing genetic circuits, and engineering regulatory RNAs in diverse bacteria. Learn more
Tae Seok Moon
Postdoctoral research at MIT and University of
California-San Francisco provided Dr. Moon with
expertise in the design and construction of genetic
circuits. As a graduate student at MIT, he learned
how to construct and optimize novel metabolic
pathways to produce biochemicals that can replace
oil-based chemicals. Combining his research
experiences with more than five years experience in
the biotechnology industry, he envisions his career
as transforming biology research from an
"observation" approach to a "synthesis-based
engineering" activity to address energy, environment
and health issues. Learn more
about Dr. Moon
Dr. Junyang Wang and Dr. Jinjin Diao join the group. Welcome!
Drew successfully defended his thesis. Congrats! Dr. DeLorenzo! We will miss you.
Yifeng Hu, Juya Jeon, and Chenggang Xi join the group as Graduate Rotation students. Welcome!
Congratulations to Drew for his paper accepted: DM DeLorenzo and TS Moon. Construction of genetic logic gates based on the T7 RNA polymerase expression system in Rhodococcus opacus PD630. ACS Synth. Biol. 10.1021/acssynbio.9b00213 (2019) Link
Congratulations to Rhiannon for our collaborative work published: W Anthony, RR Carr, DM DeLorenzo, T Campbell, Z Shang, M Foston, TS Moon and G Dantas. Development of Rhodococcus opacus as a chassis for lignin valorization and bioproduction of high-value compounds. Biotechnol Biofuels. 12:192. (2019) Link
Our collaborative work was published: GW Roell, R Carr, T Campbell, Z Shang, WR Henson, J Czajka, H Martin, F Zhang, M Foston, G Dantas, TS Moon and YJ Tang. A concerted systems biology analysis of phenol metabolism in Rhodococcus opacus PD630. Metab. Eng. 55, 120-130 (2019) Link
Congratulations to Young Je (Ryan), Soo-Jung and Matt for their paper accepted: YJ Lee, SJ Kim, MB Amrofell and TS Moon. Establishing a multivariate model for predictable antisense RNA-mediated repression. ACS Synth. Biol. Link
Drew gave a talk at the 2018 AIChE meeting.
Professor Moon gave an invited talk at Cold Spring Harbor Laboratory (CSHL Summer Course).
Congratulations to Ray and Drew for their paper published: WR Henson, T Campbell, D DeLorenzo, Y Gao, B Berla, SJ Kim, M Foston, TS Moon and G Dantas. Multi-omic elucidation of aromatic catabolism in adaptively evolved Rhodococcus opacus. Metab. Eng. 49, 69–83 (2018) Link
Ray successfully defended his thesis. Congrat! Dr. Henson! We will miss you.
Professor Moon has been promoted to the rank of Associate Professor with tenure. Congrats!
Rhiannon Carr joins the group as a grad student. Welcome!
Congratulations to Drew for his paper accepted: DM DeLorenzo and TS Moon. Selection of stable reference genes for RT-qPCR in Rhodococcus opacus PD630. Sci. Rep. 8:6019 (2018) Link
Congratulations to Drew for his paper accepted: DM DeLorenzo, AG Rottinghaus, WR Henson and TS Moon. Molecular toolkit for gene expression control and genome modification in Rhodococcus opacus PD630. ACS Synth. Biol. 10.1021/acssynbio.7b00416 Link
Moon Research Group receives a grant from the Department of Energy for “Systems Engineering of Rhodococcus opacus to Enable Production of Drop-in Fuels from Lignocellulose.” Link
Drew is highlighted in ACS Synthetic Biology's "Introducing Our Authors". Link
Pengfei Gu & Yichao Han join the group as Graduate Rotation students. Welcome!
Professor Moon gave a talk at the 2017 AIChE meeting.
Matt Amrofell joins the group as a Graduate Rotation student. Welcome!
Moon Research Group receives a grant from the National Science Foundation for “Establishing a generalizable model for predictable antisense RNA repression.” Link
Congratulations to Drew for his paper accepted: DM DeLorenzo, WR Henson and TS Moon. Development of Chemical and Metabolite Sensors for Rhodococcus opacus PD630. ACS Synth. Biol. Accepted. DOI: 10.1021/acssynbio.7b00192 Link
Professor Moon gave a talk at the Synthetic Biology Gordon Research Conference, Stowe, VT. Link
Graduation! Congrats to Caroline, Matthew, Taylor, and Blake! We wish you best of luck in graduate schools.
Professor Moon contributes to a “Voices” piece for Cell Systems. TS Moon. What Is the Role of Circuit Design in the Advancement of Synthetic Biology? Cell Systems 4, 370-372 (with 8 other contributors). Link
Professor Moon gave an invited seminar at Arizona State University.
Congratulations to Matthew Leong for being named Chemistry’s Merck Award winner.
Congratulations to Drew for his paper accepted: N Wan, DM DeLorenzo, L He, L You, CM Immethun, G Wang, EEK Baidoo, W Hollinshead, JD Keasling, TS Moon and YJ Tang. Cyanobacterial carbon metabolism: fluxome plasticity and oxygen dependence. Biotechnol. Bioeng. Accepted. DOI: 10.1002/bit.26287 (2017) Link
Congratulations to Allison for her paper accepted: A Hoynes-O’Connor, T Shopera, K Hinman, JP Creamer and TS Moon. Enabling Complex Genetic Circuits to Respond to Extrinsic Environmental Signals. Biotechnol. Bioeng. Accepted. DOI: 10.1002/bit.26279 (2017) Link
Congratulations to Cheryl for her paper accepted: CM Immethun, DM DeLorenzo, CM Focht, D Gupta, CB Johnson and TS Moon. Physical, Chemical, and Metabolic State Sensors Expand the Synthetic Biology Toolbox for Synechocystis sp. PCC 6803. Biotechnol. Bioeng. Accepted. DOI: 10.1002/bit.26275 (2017) Link
Professor Moon gave a talk at the 2017 DOE Genomic Sciences Program Meeting.
Allison is highlighted in ACS Synthetic Biology's "Introducing Our Authors". Link
Austin joins the group as a PhD student. Welcome!
Professor Moon gave two oral presentations at the 2016 AIChE meeting.
The WUSTL-PSU 2016 iGEM team received a silver medal at the iGEM Jamboree. Congrats to all members involved!
Ryan gave an oral presentation at the 2016 PMB retreat (A DBBS retreat at Tyson Research Center).
Professor Moon gave a talk in an ACS BIOT webinar.
Phillipe and Austin join the lab as graduate rotation students! Welcome everyone!
Congratulations to Allison for her paper accepted: A Hoynes-O’Connor and TS Moon. Development of design rules for reliable antisense RNA behavior in E. coli. ACS Synth. Biol. Accepted. DOI: 10.1021/acssynbio.6b00036 (2016) Link
Professor Moon gave an invited talk at the 2016 Metabolic Engineering and Green Manufacturing in Microorganisms, Beijing University of Chemical Technology.
Professor Moon gave an invited seminar at KAIST.
Professor Moon receives a Best of BIOT Award from the American Chemical Society.
Gillian Myers and Zach Glick join the lab for the summer as iGEM team members. Welcome everyone!
Cheryl gave a poster presentation at the 12th Workshop on Cyanobacteria at ASU.
Our collaborative work (with the Pakrasi, Maranas, and Zhang labs) was published: R Saha, D Liu, A Hoynes-O'Connor, M Liberton, J Yu, M Bhattacharyya-Pakrasi, A Balassy, F Zhang, TS Moon, CD Maranas and HB Pakrasi. Diurnal Regulation of Cellular Processes in the Cyanobacterium Synechocystis sp. Strain PCC 6803: Insights from Transcriptomic, Fluxomic and Physiological Analyses. mBio. 7, e00464-16 (2016) Link
Cheryl, Ray, Tatenda, Allison, and Ryan gave five poster presentations at the Monsanto Fellows Synthetic Biology Symposium.
Matthew Leong receives a 2016 BioSURF Fellowship. Congratulations, Matthew!
Andrew Ng (Moon lab alumnus, now at UC Berkeley/UCSF) receives a 2016 National Defense Science and Engineering Graduate (NDSEG) Fellowship. Congratulations, Andrew!
Ryan wins an oral presentation award at the SynBERC meeting at UC Berkeley. Congrats, Ryan!
Ryan gave an oral presentation at the SynBERC meeting at UC Berkeley. Allie also gave a poster presentation.
Professor Moon gave three oral presentations at the 251st ACS National Meeting. One of the presentations was identified as the "Best Presentation" of the Session.
Congratulations to Cheryl for receiving a Registration Scholarship for the 12th Workshop on Cyanobacteria at ASU.
Congratulations to Cheryl for her book chapter published: CM Immethun, WR Henson, X Wang, D Nielsen and TS Moon. Engineering Central Metabolism for Production of Higher Alcohol-based Biofuels, Chapter 1, p1-34 in "Biotechnologies for Biofuel Production and Optimization" (CA Eckert & CT Trinh, Ed). Elsevier. Link
Congratulations to Ray for his paper accepted: A Yoneda, WR Henson, NK Goldner, KJ Park, KJ Forsberg, SJ Kim, MW Pesesky, M Foston, G Dantas and TS Moon. Comparative transcriptomics elucidates adaptive phenol tolerance and utilization in lipid-accumulating Rhodococcus opacus PD630. Nucleic Acids Res. Link
Cheryl, Ray, Tatenda, and Allison gave oral presentations at the 2015 AIChE annual meeting.
Mike gave a poster presentation in the Undergraduate Research Symposium at WashU.
Professor Moon gave an invited talk at the Washington University Biomedical Engineering Department.
Congratulations to Tatenda for his paper published: T Shopera, WR Henson, A Ng, YJ Lee, K Ng and TS Moon. Robust, tunable genetic memory from protein sequestration combined with positive feedback. Nucleic Acids Res. DOI: 10.1093/nar/gkv936 (2015) Link
Cameron and Eugene join the lab as graduate rotation students! Welcome everyone!
Congratulations to Cheryl for her paper accepted: CM Immethun, KM Ng, DM DeLorenzo, B Waldron-Feintstein, YC Lee and TS Moon. Oxygen-Responsive Genetic Circuits Constructed in Synechocystis sp. PCC6803. Biotechnol. Bioeng. DOI: 10.1002/bit.25722 (2015)
Congratulations to Ray for his paper accepted: WD Hollinshead, WR Henson, M Abernathy, TS Moon and YJ Tang. Rapid Metabolic Analysis of Rhodococcus opacus PD630 via parallel 13C-Metabolite Fingerprinting, Biotechnol. Bioeng. DOI: 10.1002/bit.25702 (2015)
Congratulations to Allison for her paper published online: A Hoynes-O’Connor, K Hinman, L Kirchner and TS Moon. De novo design of heat-repressible RNA thermosensors in E. coli. Nucleic Acids Res. doi: 10.1093/nar/gkv499 (2015). Link
Kenneth gave a poster presentation at the 3rd Annual Global Health and Infectious Disease Conference.
Ray gave a featured oral presentation at the 2015 Annual Conference for the Institute for Biological Engineering.
Cheryl, Allison, and Tatenda each gave oral presentations at the Annual IBE Conference.
The 2014 WashU iGEM team gave an oral presentation at the IBE conference.
Professor Moon gave three oral presentations including an invited talk at the 2014 AIChE conference.
Cheryl & Allison gave oral presentations at the 2014 AIChE conference.
Professor Moon gave an invited lecture at the Indo-US Workshop on Synthetic & Systems Biology (JNU, New Delhi, India) to discuss the potential and risks of synthetic biology. https://sites.google.com/site/synbioworkshop/synbioglobal
Wei Bai joins the lab as a graduate rotation student! Welcome!
The WUSTL 2014 iGEM team received a silver medal at the iGEM Giant Jamboree. Congrats to all members involved!
Ray and Tatenda presented posters at the SynBERC meeting at MIT.
Professor Moon gave an invited talk at the SynBERC meeting at MIT.
Drew Delorenzo, Charlie Johnson, Yu He, and Ben Wolf join the lab as graduate rotation students! Welcome everyone!
Allison Hoynes-O'Connor wins a poster presentation award at the 2014 SIMB conference! Congrats, Allison!
Cheryl, Allison, and Ray presented posters at the 2014 SIMB conference.
Professor Moon gave an invited talk at the 2014 Annual Meeting of the Society for Industrial Microbiology & Biotechnology (SIMB), click here for more info.
Professor Moon gave a talk at the inaugural SEED conference (the Synthetic Biology: Engineering, Evolution & Design), click here for more info.
paper published online: B Thompson, TS Moon and D
Nielsen. ‘Hybrid’ Processing Strategies for
Expanding and Improving the Synthesis of Renewable
Bioproducts, Curr. Opin. Biotechnol. 30, 17-23
Allison, Cheryl, and Ray
in the Moon lab received project funding from
Women's Society of Washington University for the
outreach activities which include teaching kit
development for Teach For America Teachers!
Please contact Allie at firstname.lastname@example.org
for more information!
Kenneth Ng joins the lab as a research technician! Welcome Kenneth!
Research Group receives a grant from the National
Science Foundation for "Designing Nitrogen Fixing
Ability in Oxygenic Photosynthetic Cells."
Paper highlighted as Featured Article in
Frontiers in Microbiology!
Moon Research Group
receives an I-CARES Research Award for "Hybrid
Conversion of Lignin: Trees to Fat" with
collaborator Professor Marcus Foston, also from EECE
at Washington University in St. Louis.
Ray Henson, Allison
Hoynes-O'Connor, and Tatenda Shopera join the group
as PhD candidates. Welcome Ray, Allison and
Professor Moon is
highlighted in ACS Synthetic Biology's
"Introducing Our Authors".
CM Immethun, AG Hoynes-O’Connor, A Balassy and TS Moon. Microbial Production of Isoprenoids Enabled by Synthetic Biology, Invited review, accepted in Frontiers in Microbiology.
Ray Henson and Tatenda Shopera join the group as Graduate Rotation students. Welcome Ray and Tatenda!